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<p>Formation of abdominal adhesions is accompanied by the synthesis of collagen monomers by fibroblasts and deposition of type I and III collagens. This process is regulated by various factors, including TIMP-1, MMP-1, TGFβ, IL-10, and IFNγ. Oxidized dextran prevents fibrosis, adhesion formation, affecting the functional state of macrophages and fibroblasts. Collagen formation and fibroblasts in abdominal adhesions of Wistar rats were studied against the background of intraperitoneal administration of oxidized dextran. Electron and light microscopy and immunohistochemical method (collagen I, TIMP-1, MMP-9, FGF) were used. Administration of oxidized dextran prevented tropocollagen secretion into the extracellular matrix, the assembly of collagen I fibers, while functional activity of fibroblasts was preserved, and was accompanied by fibroblast apoptosis. Macrophages formed contacts with fibroblasts and phagocytosed apoptotic cells.</p>

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Molecular and Cellular Mechanisms of Fibrosis of Abdominal Adhesions under the Influence of Oxidized Dextran in the Experiment

  • 期刊论文

  • 发表日期：

    2025年10月1日

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  • M. A. Karpov,
  • A. P. Nadeev,
  • V. A. Shkurupy,
  • N. P. Bgatova,
  • A. V. Basova,
  • M. A. Volchek,
  • A. V. Volchek,
  • A. V. Kuznetsov,
  • E. V. Ovsyanko,
  • S. V. Pozdnyakova

摘要

Formation of abdominal adhesions is accompanied by the synthesis of collagen monomers by fibroblasts and deposition of type I and III collagens. This process is regulated by various factors, including TIMP-1, MMP-1, TGFβ, IL-10, and IFNγ. Oxidized dextran prevents fibrosis, adhesion formation, affecting the functional state of macrophages and fibroblasts. Collagen formation and fibroblasts in abdominal adhesions of Wistar rats were studied against the background of intraperitoneal administration of oxidized dextran. Electron and light microscopy and immunohistochemical method (collagen I, TIMP-1, MMP-9, FGF) were used. Administration of oxidized dextran prevented tropocollagen secretion into the extracellular matrix, the assembly of collagen I fibers, while functional activity of fibroblasts was preserved, and was accompanied by fibroblast apoptosis. Macrophages formed contacts with fibroblasts and phagocytosed apoptotic cells.