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<p>Mice were subjected to vestibular stimulation (rotation at 80 rpm for 8 h) and behavioral disturbances and morphological changes in the Deiters’ vestibular nuclei were studied 1 h and 2, 5, and 7 days after stimulation. Horizontal and vertical motor activity decreased after long-term vestibular stimulation and recovered after 1 day. Short- and long-term disturbances in the morphology of Deiters’ neurons and neuropil were detected. Disturbances in the structure of neurons were no longer detected 2 days after stimulation, while disturbances in myelinated axons in the neuropil persisted for up to 7 days. These disturbances manifested by abnormal water distribution and pronounced damage to the myelin sheath. It is assumed that long-term edema of myelinated axons is a target for therapeutic intervention in diseases associated with axonal demyelination.</p>

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Dynamics of Morphological Changes of Axons in the Lateral (Deiters) Vestibular Nuclei in Mice after Long-Term Stimulation

  • 期刊论文

  • 发表日期：

    2025年10月1日

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  • I. B. Mikheeva,
  • N. S. Zhuikova,
  • L. L. Pavlik,
  • V. I. Arkhipov

摘要

Mice were subjected to vestibular stimulation (rotation at 80 rpm for 8 h) and behavioral disturbances and morphological changes in the Deiters’ vestibular nuclei were studied 1 h and 2, 5, and 7 days after stimulation. Horizontal and vertical motor activity decreased after long-term vestibular stimulation and recovered after 1 day. Short- and long-term disturbances in the morphology of Deiters’ neurons and neuropil were detected. Disturbances in the structure of neurons were no longer detected 2 days after stimulation, while disturbances in myelinated axons in the neuropil persisted for up to 7 days. These disturbances manifested by abnormal water distribution and pronounced damage to the myelin sheath. It is assumed that long-term edema of myelinated axons is a target for therapeutic intervention in diseases associated with axonal demyelination.