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<p>Na,K-ATPase activity is critical for maintaining electrogenesis and skeletal muscle function. Isolated rat diaphragm muscles were studied after 3-h high-altitude hypobaric hypoxia (HAH, corresponds to an altitude of 6000 m) in a pressure chamber. LPO activation was observed over 24 h after HAH; no significant changes in other markers of oxidative stress and energy metabolism were detected. During this period, stable hyperpolarization of the sarcolemma developed due to increased electrogenic activity of the α2-Na,K-ATPase isoform, while the total muscle level of the α2-subunit protein remained unchanged. Our findings may have practical implications for developing measures to maintain skeletal muscle functions during high-altitude adaptation.</p>

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Short-Term Simulated High-Altitude Hypoxia Enhances Na,K-ATPase Efficiency in Maintaining Rat Diaphragm Electrogenesis

  • 期刊论文

  • 发表日期：

    2025年10月1日

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  • V. V. Kravtsova,
  • A. A. Fedorova,
  • V. O. Matytsin,
  • D. D. Ganke,
  • O. V. Vetrovoy,
  • I. I. Krivoi

摘要

Na,K-ATPase activity is critical for maintaining electrogenesis and skeletal muscle function. Isolated rat diaphragm muscles were studied after 3-h high-altitude hypobaric hypoxia (HAH, corresponds to an altitude of 6000 m) in a pressure chamber. LPO activation was observed over 24 h after HAH; no significant changes in other markers of oxidative stress and energy metabolism were detected. During this period, stable hyperpolarization of the sarcolemma developed due to increased electrogenic activity of the α2-Na,K-ATPase isoform, while the total muscle level of the α2-subunit protein remained unchanged. Our findings may have practical implications for developing measures to maintain skeletal muscle functions during high-altitude adaptation.