<p>The studied substances of the prostate extract have vasomotor activity of varying degree. The substance-mixture Prostatilen at concentrations of 2 and 5 μg/ml causes a positive chronotropic effect increasing the frequency of contractions by 23.7% (<i>p</i> ⩽ 0.01) and 37.6% (<i>p</i> ⩽ 0.01), respectively. The substance-powder Samprost did not affect motor activity of lymphatic vessels at a concentration of 2 μg/ml and inhibited the frequency of contractions by 6.7% (<i>p</i> ⩽ 0.05) at a concentration of 5 μg/ml. The substance Biofac at a concentration of 2 μg/ml has a negative effect on the motor activity of lymphangions changing the parameters of contractile activity in different directions, and at a concentration of 5 μg/ml it inhibits the contractile activity of lymphatic vessels (a 14.2% decrease in contraction frequency; <i>p</i> ⩽ 0.05).</p>

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Comparative Assessment of the Influence of Active Pharmacological Substances of Prostate Extract on the Contractile Activity of Rat Lymphatic Vessels

  • O. V. Nechaykina,
  • D. S. Laptev,
  • S. G. Petunov,
  • D. V. Bobkov,
  • T. A. Kudryavtseva

摘要

The studied substances of the prostate extract have vasomotor activity of varying degree. The substance-mixture Prostatilen at concentrations of 2 and 5 μg/ml causes a positive chronotropic effect increasing the frequency of contractions by 23.7% (p ⩽ 0.01) and 37.6% (p ⩽ 0.01), respectively. The substance-powder Samprost did not affect motor activity of lymphatic vessels at a concentration of 2 μg/ml and inhibited the frequency of contractions by 6.7% (p ⩽ 0.05) at a concentration of 5 μg/ml. The substance Biofac at a concentration of 2 μg/ml has a negative effect on the motor activity of lymphangions changing the parameters of contractile activity in different directions, and at a concentration of 5 μg/ml it inhibits the contractile activity of lymphatic vessels (a 14.2% decrease in contraction frequency; p ⩽ 0.05).