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<p>We studied the effectiveness of poloxamer-188 solution (Myotive) administered orally and intravenously at a dose of 48 mg/kg to female BALB/c mice before and after inoculation of colon carcinoma. After oral and intravenous administration of the poloxamer, active tumor necrosis and body weight loss for this reason were observed; a decrease in the tumor volume and normalization of the differential blood cell count and hematological parameters were also seen. Thus, poloxamer-188 is a promising antitumor agent presumably affecting the modified lipid bilayer of tumor cells.</p>

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Antitumor Activity of Poloxamer-188 Solution (Myotive) after Oral and Intravenous Administration in Female BALB/c Mice

  • 期刊论文

  • 发表日期：

    2025年10月1日

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  • D. I. Rzhevskiy,
  • R. A. Dalevich,
  • I. N. Kravchenko,
  • E. S. Sadovnikova,
  • S. G. Semushina,
  • G. A. Slascheva,
  • V. A. Kazakov,
  • N. A. Borozdina,
  • V. A. Palikov,
  • N. M. Pankratova,
  • A. N. Pankratov,
  • I. A. Dyachenko,
  • E. V. Arshintseva,
  • S. Yu. Pushkin

摘要

We studied the effectiveness of poloxamer-188 solution (Myotive) administered orally and intravenously at a dose of 48 mg/kg to female BALB/c mice before and after inoculation of colon carcinoma. After oral and intravenous administration of the poloxamer, active tumor necrosis and body weight loss for this reason were observed; a decrease in the tumor volume and normalization of the differential blood cell count and hematological parameters were also seen. Thus, poloxamer-188 is a promising antitumor agent presumably affecting the modified lipid bilayer of tumor cells.