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<p>Immunofluorescence analysis was used to study the expression pattern of macrophage colony-stimulating factor 1 (CSF-1) in spinal cord cells in a murine model of multiple sclerosis (experimental autoimmune encephalomyelitis). Marked upregulation of CSF-1<sup>+</sup> signal was observed in spinal cord astrocytes in both acute and chronic stages of the disease. These findings suggest a potential role for CSF-1 in the pathogenesis and progression of experimental autoimmune encephalomyelitis/multiple sclerosis.</p>

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Expression of Macrophage Colony-Stimulating Factor 1 (CSF-1) by Spinal Cord Astrocytes in Mice with Experimental Autoimmune Encephalomyelitis

  • 期刊论文

  • 发表日期：

    2025年10月1日

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  • A. V. Balashov,
  • V. P. Balashov,
  • N. P. Shikhanov,
  • E. V. Bystrova,
  • S. V. Gushchina

摘要

Immunofluorescence analysis was used to study the expression pattern of macrophage colony-stimulating factor 1 (CSF-1) in spinal cord cells in a murine model of multiple sclerosis (experimental autoimmune encephalomyelitis). Marked upregulation of CSF-1+ signal was observed in spinal cord astrocytes in both acute and chronic stages of the disease. These findings suggest a potential role for CSF-1 in the pathogenesis and progression of experimental autoimmune encephalomyelitis/multiple sclerosis.