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<p>We studied the effect of an anthocyanin-containing complex from <i>Aronia melanocarpa</i> (<i>Michx</i>.) Elliott on the main indicators of erythropoiesis in the peripheral blood and bone marrow of mice with Lewis lung carcinoma against the background of doxorubicin treatment. It was found that administration of the anthocyanin-containing complex from <i>A. melanocarpa</i> (<i>Michx</i>.) Elliott to tumor-bearing animals prevents the development of anemic syndrome via stimulation of the erythropoiesis recovery after its inhibition by the cytostatic agent. The mechanisms of erythropoiesis stimulation by the plant-derived complex involve systems of local and distant regulation of proliferation and differentiation of committed erythroid progenitor cells.</p>

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Erythropoiesis-Stimulating Action of Anthocyan-Containing Complex from Aronia melanocarpa (Michx.) Elliott in Experimental Cytostatic Therapy

  • 期刊论文

  • 发表日期：

    2025年9月1日

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  • O. Yu. Rybalkina,
  • E. P. Fedorova,
  • A. V. Chaikovskii,
  • N. S. Selivanova,
  • T. G. Razina,
  • G. I. Kalinkina,
  • V. Yu. Andreeva,
  • O. V. Voronkova,
  • E. P. Zueva,
  • M. V. Belousov,
  • V. V. Zhdanov

摘要

We studied the effect of an anthocyanin-containing complex from Aronia melanocarpa (Michx.) Elliott on the main indicators of erythropoiesis in the peripheral blood and bone marrow of mice with Lewis lung carcinoma against the background of doxorubicin treatment. It was found that administration of the anthocyanin-containing complex from A. melanocarpa (Michx.) Elliott to tumor-bearing animals prevents the development of anemic syndrome via stimulation of the erythropoiesis recovery after its inhibition by the cytostatic agent. The mechanisms of erythropoiesis stimulation by the plant-derived complex involve systems of local and distant regulation of proliferation and differentiation of committed erythroid progenitor cells.