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<p>We studied the effects of exogenous melatonin (administrated <i>ad libitum</i> at a concentration of 4 mg/liter in drinking water for 4 weeks) on the differentiation of B lymphocytes (PAX-5<sup>+</sup>) and apoptosis (Casp3<sup>+</sup>) of spleen cells in outbred laboratory mice kept under conditions of natural photoperiod, constant darkness, or constant illumination. Constant darkness increased the number of B-lymphocyte precursors and caspase-3 lymphocytes in the lymphoid follicles of the spleen. Constant light exposure reduced the number of B lymphocyte precursors, increased the number of Casp3<sup>+</sup> lymphocytes and the content of caspase-3 and transcription factor PAX-5 in these cells. Melatonin administration under artificial photoperiods (24/24 and 0/24 regimens) reduced the number of Casp3<sup>+</sup> cells and increased the number of PAX-5<sup>+</sup> cells in the white pulp.</p>

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Influence of Photoperiod and Exogenous Melatonin on the Maturation and Apoptosis of B Lymphocytes in the Spleen

  • 期刊论文

  • 发表日期：

    2025年9月1日

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  • E. M. Luzikova,
  • O. A. Efremova,
  • N. E. Gimaldinova,
  • O. I. Moskovskaya,
  • L. P. Romanova,
  • I. M. Dyachkova,
  • V. M. Levitskaya,
  • E. A. Denisova

摘要

We studied the effects of exogenous melatonin (administrated ad libitum at a concentration of 4 mg/liter in drinking water for 4 weeks) on the differentiation of B lymphocytes (PAX-5+) and apoptosis (Casp3+) of spleen cells in outbred laboratory mice kept under conditions of natural photoperiod, constant darkness, or constant illumination. Constant darkness increased the number of B-lymphocyte precursors and caspase-3 lymphocytes in the lymphoid follicles of the spleen. Constant light exposure reduced the number of B lymphocyte precursors, increased the number of Casp3+ lymphocytes and the content of caspase-3 and transcription factor PAX-5 in these cells. Melatonin administration under artificial photoperiods (24/24 and 0/24 regimens) reduced the number of Casp3+ cells and increased the number of PAX-5+ cells in the white pulp.