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<p>The TNFα content in the blood serum of 109 patients with uterine fibroids was studied. Cytokine concentrations ranged from 4.65 to 25.88 pg/ml regardless of the clinical parameters of the disease, but were associated with complex genotypes of different structural and functional organization (<i>TNFA</i>, <i>IL1B</i>, <i>IL4</i>, <i>IL6</i>, <i>IL8</i>, <i>IL10</i>, <i>IL17A</i>, <i>VEGFA</i>, <i>MMP2</i>, <i>MMP3</i>, <i>MMP9</i>). The interaction of multiple genes that affect the level of serum TNFα production has been revealed. In particular, on the one hand, the complex genotype <i>TNF-308GG/VEGF-2578CA</i> is positively associated with high levels of TNFα (OR = 10.00, <i>p</i><sub>cor</sub> = 0.0274), and on the other hand, the combined genotype of 4 polymorphisms <i>TNF-308GG/TNF-238GG/VEGF-2578AA/MMP2-1306CC</i> is closely associated with its low level (OR = 25.00, <i>p</i><sub>cor</sub> = 0.0469). The obtained results allow better understand the mechanisms of the manifestation of the genetic predisposition to uterine fibroids associated with the presence in the genome of highly specific gene compositions that underlie tumorogenesis in this disease.</p>

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Genetic Loci of TNFα Level Regulation in Blood Serum of Women with Uterine Fibroids

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • V. I. Konenkov,
  • V. F. Prokofiev,
  • A. V. Shevchenko,
  • E. G. Koroleva

摘要

The TNFα content in the blood serum of 109 patients with uterine fibroids was studied. Cytokine concentrations ranged from 4.65 to 25.88 pg/ml regardless of the clinical parameters of the disease, but were associated with complex genotypes of different structural and functional organization (TNFA, IL1B, IL4, IL6, IL8, IL10, IL17A, VEGFA, MMP2, MMP3, MMP9). The interaction of multiple genes that affect the level of serum TNFα production has been revealed. In particular, on the one hand, the complex genotype TNF-308GG/VEGF-2578CA is positively associated with high levels of TNFα (OR = 10.00, pcor = 0.0274), and on the other hand, the combined genotype of 4 polymorphisms TNF-308GG/TNF-238GG/VEGF-2578AA/MMP2-1306CC is closely associated with its low level (OR = 25.00, pcor = 0.0469). The obtained results allow better understand the mechanisms of the manifestation of the genetic predisposition to uterine fibroids associated with the presence in the genome of highly specific gene compositions that underlie tumorogenesis in this disease.