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<p>The valproate model of autism was used to evaluate the effect of a course of dimephosphone administration (intragastric, 50 mg/kg, 30 days) on contractions of the isolated bladder of rats induced by application of carbacholine (10<sup>–7</sup>-10<sup>–5</sup> M), α,β-methylene-ATP (10<sup>–7</sup>-10<sup>–5</sup> M), and stimulation with an electric field of different frequencies (1-20 Hz). In rats with the valproate model of autism, the strength of carbacholine-induced bladder contractions was significantly higher than in control (intact) rats. Against the background of dimephosphone administration, carbacholine-induced contractions reached the control level. Similar results were obtained with electric field stimulation. However, when evaluating the effect of dimephosphone on bladder contractions caused by α,β-methylene-ATP, no significant changes were found. Dimephosphone, when administered in a course, normalizes bladder contractility in rats with the valproate model of autism.</p>

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Effect of Dimephosphone on the Mechanical Activity of the Bladder in Rats with a Model of Autism

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • A. M. Zyapbarov,
  • A. S. Bakanova,
  • D. V. Ivanova,
  • A. U. Ziganshin

摘要

The valproate model of autism was used to evaluate the effect of a course of dimephosphone administration (intragastric, 50 mg/kg, 30 days) on contractions of the isolated bladder of rats induced by application of carbacholine (10–7-10–5 M), α,β-methylene-ATP (10–7-10–5 M), and stimulation with an electric field of different frequencies (1-20 Hz). In rats with the valproate model of autism, the strength of carbacholine-induced bladder contractions was significantly higher than in control (intact) rats. Against the background of dimephosphone administration, carbacholine-induced contractions reached the control level. Similar results were obtained with electric field stimulation. However, when evaluating the effect of dimephosphone on bladder contractions caused by α,β-methylene-ATP, no significant changes were found. Dimephosphone, when administered in a course, normalizes bladder contractility in rats with the valproate model of autism.