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<p>We studied the effect of a protein kinase A (PKA) inhibitor and the content of different types of progenitor cells in the subventricular zone of the brain of 16-month-old male C57BL/6 mice (characterized by pathological endogenous amyloid formation in the brain) and on the mental status of these mice. The pharmacological agent ameliorated disorders of orientation and exploratory behavior and conditioned response performance in experimental animals. At the same time, an increase in the content of resident neural stem cells and committed neuronal precursors in the nervous tissue was found.</p>

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Psychopharmacological and Neuroregenerative Properties of Protein Kinase A Inhibitor in Alzheimer’s Disease Model

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • G. N. Zyuz’kov,
  • V. V. Zhdanov,
  • L. A. Miroshnichenko,
  • T. Yu. Polyakova,
  • A. V. Chaykovskyi,
  • V. I. Agafonov

摘要

We studied the effect of a protein kinase A (PKA) inhibitor and the content of different types of progenitor cells in the subventricular zone of the brain of 16-month-old male C57BL/6 mice (characterized by pathological endogenous amyloid formation in the brain) and on the mental status of these mice. The pharmacological agent ameliorated disorders of orientation and exploratory behavior and conditioned response performance in experimental animals. At the same time, an increase in the content of resident neural stem cells and committed neuronal precursors in the nervous tissue was found.