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<p>Transdermal drug delivery is an effective method of drug administration, and for certain substances, it may be the only viable option. The most efficient and advanced approach to implementation of this method is the use of microneedles made from biodegradable materials. The method for producing transdermal patches with microneedles has been proposed, including techniques for their biodegradation and implantation <i>in vivo</i>. This method involves creating a 3D model of the patch master form, printing it with a 3D printer, creating a mold from polydimethylsiloxane, and then casting the patch from a biopolymer such as PLGA, PLA, DL-PLA, or PDLLA. Among these biopolymers, PLGA has demonstrated better biodegradation properties in comparison with the others. The implantation of patches with a universal animal harness has been found to be the most effective method.</p>

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An Assessment of the Biodegradation of Microneedles and Methods of Their Implantation for Transdermal Drug Administration

  • 期刊论文

  • 发表日期：

    2025年7月1日

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  • E. V. Edemskaya,
  • G. G. Zasypkin,
  • E. Yu. Podyacheva,
  • Y. G. Toropova,
  • D. V. Korolev

摘要

Transdermal drug delivery is an effective method of drug administration, and for certain substances, it may be the only viable option. The most efficient and advanced approach to implementation of this method is the use of microneedles made from biodegradable materials. The method for producing transdermal patches with microneedles has been proposed, including techniques for their biodegradation and implantation in vivo. This method involves creating a 3D model of the patch master form, printing it with a 3D printer, creating a mold from polydimethylsiloxane, and then casting the patch from a biopolymer such as PLGA, PLA, DL-PLA, or PDLLA. Among these biopolymers, PLGA has demonstrated better biodegradation properties in comparison with the others. The implantation of patches with a universal animal harness has been found to be the most effective method.