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<p>Stabilized trimers of the HIV-1 Env surface glycoprotein are considered as one of the main directions in the design of an HIV-1 vaccine, both individually and in prime-boost immunization strategies. The article presents the results of a study of the immunogenicity of the Env trimer of the recombinant HIV-1 CRF63_02A6 in the form of a recombinant protein and a DNA vaccine, as well as in the prime-boost immunization scheme. The Env trimer in the form of a protein and a DNA vaccine induced the formation of specific antibodies with virus-neutralizing activity against HIV-1 Env-pseudoviruses.</p>

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Immunogenicity of the Stabilized Env Trimer HIV-1 CRF63_02A6 Produced in Protein and DNA Vaccine Formats

  • 期刊论文

  • 发表日期：

    2025年7月1日

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  • N. B. Rudometova,
  • A. P. Rudometov,
  • A. A. Fando,
  • L. A. Kisakova,
  • D. N. Kisakov,
  • E. V. Tigeeva,
  • V. A. Yakovlev,
  • M. B. Borgoyakova,
  • D. N. Shcherbakov,
  • A. A. Ilyichev,
  • L. I. Karpenko

摘要

Stabilized trimers of the HIV-1 Env surface glycoprotein are considered as one of the main directions in the design of an HIV-1 vaccine, both individually and in prime-boost immunization strategies. The article presents the results of a study of the immunogenicity of the Env trimer of the recombinant HIV-1 CRF63_02A6 in the form of a recombinant protein and a DNA vaccine, as well as in the prime-boost immunization scheme. The Env trimer in the form of a protein and a DNA vaccine induced the formation of specific antibodies with virus-neutralizing activity against HIV-1 Env-pseudoviruses.