Scholarlink

<p>We have shown that changes in the phospholipid and fatty acid composition of atherosclerotic plaques in the carotid arteries of patients who underwent carotid endarterectomy in combination with coronary artery bypass surgery are linked with the development of the pathological process and highlight the importance of cytochrome C-mediated induction of oxidation of membrane phospholipids. An increase of the steady-state equilibrium constant of cytochrome C with atherosclerotic membranes to 10<sup>–5</sup> M and simultaneously a more than three-fold enhancement of LPO process are demonstrated.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Cytochrome C-Dependent Processes of Damage of Atherosclerotic Plaque Membranes Regulated by Anionic Phospholipids Containing Saturated and Unsaturated Fatty Acids

  • 期刊论文

  • 发表日期：

    2025年7月1日

查看全文
  • G. O. Stepanov,
  • V. V. Volkov,
  • S. P. Konukhova,
  • A. A. Struchkova,
  • Yu. A. Vladimirov,
  • A. N. Osipov,
  • A. V. Tarasov,
  • R. S. Akchurin,
  • D. M. Galyautdinov,
  • V. P. Masenko,
  • O. V. Stepanova

摘要

We have shown that changes in the phospholipid and fatty acid composition of atherosclerotic plaques in the carotid arteries of patients who underwent carotid endarterectomy in combination with coronary artery bypass surgery are linked with the development of the pathological process and highlight the importance of cytochrome C-mediated induction of oxidation of membrane phospholipids. An increase of the steady-state equilibrium constant of cytochrome C with atherosclerotic membranes to 10–5 M and simultaneously a more than three-fold enhancement of LPO process are demonstrated.