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<p>We propose a method for the quantitative determination of serotonin in blood serum using high-performance liquid chromatography with tandem mass spectrometry detection (HPLC-MS/MS) and online solid-phase extraction in a chromatographic system. This approach allows serotonin quantification in blood serum within a range of 0.5-2000 ng/ml, partially automates the sample preparation process, and minimizes the influence of matrix components. The method is designed for the quantitative measurement of serotonin levels in patients with various deviations of serotonin levels and associated diseases.</p>

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Analysis of Serum Serotonin by High-Performance Liquid Chromatography–Tandem Mass Spectrometry Using Online Solid-Phase Extraction

  • 期刊论文

  • 发表日期：

    2025年6月1日

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  • D. V. Bychenkov,
  • V. A. Ioutsi,
  • I. V. Kirilina,
  • M. V. Ovcharov,
  • M. A. Antsupova,
  • A. K. Lubenskaya,
  • L. K. Abdullaev,
  • S. A. Pantsernaya,
  • N. G. Mokrysheva

摘要

We propose a method for the quantitative determination of serotonin in blood serum using high-performance liquid chromatography with tandem mass spectrometry detection (HPLC-MS/MS) and online solid-phase extraction in a chromatographic system. This approach allows serotonin quantification in blood serum within a range of 0.5-2000 ng/ml, partially automates the sample preparation process, and minimizes the influence of matrix components. The method is designed for the quantitative measurement of serotonin levels in patients with various deviations of serotonin levels and associated diseases.