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<p>Data on the distribution of insulin biosynthesis enzymes in the developing human pancreas are limited and do not provide comprehensive understanding of mechanisms of β-cell maturation. In this study, the distribution of prohormone convertase 1/3 (PC1/3) in β and α cells of the pancreas of 15 fetuses (gestational age 8-20 weeks) was analyzed using double immunofluorescence staining. It has been demonstrated that numerous cells positively stained for PC1/3 but not containing insulin are present in the pancreatic islets during prenatal development. These cells probably represent maturing β cells that accumulate the enzyme prior to the insulin biosynthesis. In some of these cells, co-localization of PC1/3 and glucagon was revealed, which indicates a possible temporary expression of glucagon in differentiating and maturing β cells.</p>

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Distribution of Prohormone Convertase 1/3 in β and α Cells of the Human Fetal Pancreas at Gestational Weeks 8-20

  • 期刊论文

  • 发表日期：

    2025年6月1日

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  • Yu. S. Krivova,
  • A. E. Proshchina,
  • O. S. Godovalova,
  • E. G. Otlyga,
  • S. V. Saveliev

摘要

Data on the distribution of insulin biosynthesis enzymes in the developing human pancreas are limited and do not provide comprehensive understanding of mechanisms of β-cell maturation. In this study, the distribution of prohormone convertase 1/3 (PC1/3) in β and α cells of the pancreas of 15 fetuses (gestational age 8-20 weeks) was analyzed using double immunofluorescence staining. It has been demonstrated that numerous cells positively stained for PC1/3 but not containing insulin are present in the pancreatic islets during prenatal development. These cells probably represent maturing β cells that accumulate the enzyme prior to the insulin biosynthesis. In some of these cells, co-localization of PC1/3 and glucagon was revealed, which indicates a possible temporary expression of glucagon in differentiating and maturing β cells.