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<p>Plasma levels of 16:0/18:1PEth is as a laboratory blood marker of alcohol consumption. In a longitudinal cohort study, the plasma levels of 16:0/18:1PEth were measured in women at different gestational periods and the results were compared with the data from three alternative questionnaires of alcohol consumption during pregnancy. Pregnant women (<i>n</i> = 309) were surveyed using T-ACE, TWEAK, and AUDIT questionnaires followed by measurement of 16:0/18:1PEth by HPLC-MS. According to the survey, 61% of pregnant women had an experience of drinking alcohol before the onset of current pregnancy. Objectively, 60, 51, and 49% of involved women had blood plasma levels of 16:0/18:1PEth exceeding 8 ng/ml in the first, second, and third trimesters. The laboratory-confirmed frequency of alcohol consumption in pregnant women is significantly higher (<i>p</i> &lt; 0.001) than in the survey.</p>

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Phosphatidylethanol 16:0/18:1PEth as a Biomarker of Alcohol Consumption during Pregnancy

  • 期刊论文

  • 发表日期：

    2025年6月1日

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  • E. V. Belyaeva,
  • A. N. Karacheva,
  • T. A. Bairova,
  • N. V. Semenova,
  • A. V. Belskikh,
  • A. Yu. Marianian,
  • E. A. Novikova,
  • O. A. Nikitina,
  • A. Yu. Sambyalova,
  • O. A. Ershova,
  • D. P. Tiumentceva,
  • L. I. Kolesnikova

摘要

Plasma levels of 16:0/18:1PEth is as a laboratory blood marker of alcohol consumption. In a longitudinal cohort study, the plasma levels of 16:0/18:1PEth were measured in women at different gestational periods and the results were compared with the data from three alternative questionnaires of alcohol consumption during pregnancy. Pregnant women (n = 309) were surveyed using T-ACE, TWEAK, and AUDIT questionnaires followed by measurement of 16:0/18:1PEth by HPLC-MS. According to the survey, 61% of pregnant women had an experience of drinking alcohol before the onset of current pregnancy. Objectively, 60, 51, and 49% of involved women had blood plasma levels of 16:0/18:1PEth exceeding 8 ng/ml in the first, second, and third trimesters. The laboratory-confirmed frequency of alcohol consumption in pregnant women is significantly higher (p < 0.001) than in the survey.