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<p>The development of artificial polyepitope immunogens based on the conserved CD4<sup>+</sup> and CD8<sup>+</sup> epitopes from different virus proteins combined into a single molecule is a promising approach in the development of vaccines for activating a specific T-cell response. Selection of spacer sequences flanking the epitopes within the construct and providing the optimal processing of such immunogens within the cell is an important step in the design of such vaccines. We report the results of designing polyepitope T-cell immunogens of tick-borne encephalitis virus that differ in the presence or absence of optimally selected alanine spacers between epitopes, as well as the data of comparative analysis of immunogenic properties of DNA vaccines encoding the obtained polyepitope immunogens.</p>

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The Immunogenicity of an Artificial Tick-Borne Encephalitis Virus Polyepitope Immunogen May Depend on Spacers Flanking Epitope

  • 期刊论文

  • 发表日期：

    2025年6月1日

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  • E. V. Tigeeva,
  • E. V. Shaburova,
  • D. V. Antonets,
  • D. N. Kisakov,
  • M. B. Borgoyakova,
  • E. V. Starostina,
  • V. A. Yakovlev,
  • L. A. Kisakova,
  • N. B. Rudometova,
  • A. P. Rudometov,
  • L. I. Karpenko

摘要

The development of artificial polyepitope immunogens based on the conserved CD4+ and CD8+ epitopes from different virus proteins combined into a single molecule is a promising approach in the development of vaccines for activating a specific T-cell response. Selection of spacer sequences flanking the epitopes within the construct and providing the optimal processing of such immunogens within the cell is an important step in the design of such vaccines. We report the results of designing polyepitope T-cell immunogens of tick-borne encephalitis virus that differ in the presence or absence of optimally selected alanine spacers between epitopes, as well as the data of comparative analysis of immunogenic properties of DNA vaccines encoding the obtained polyepitope immunogens.