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<p>The possibility of enhancing the immune response to a DNA vaccine encoding an artificial polyepitope T-cell immunogen containing a large number of conserved epitopes from different proteins of SARS-CoV-2 virus (pBSI-COV-Ub) was assessed by additional introduction of a plasmid encoding the secreted receptor-binding domain of the of SARS-CoV-2 S protein (pVAXrbd). Both a specific humoral response and a cellular response of broad specificity were observed in animals co-injected with pBSI-COV-Ub and pVAXrbd. This indicates the potential of this approach as a vaccine strategy.</p>

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Immunogenicity of DNA Vaccines against COVID-19 That Encode B- and T-Cell Immunogens after Combined Injection

  • 期刊论文

  • 发表日期：

    2025年6月1日

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  • M. B. Borgoyakova,
  • A. P. Rudometov,
  • E. V. Starostina,
  • A. M. Zadorozhny,
  • E. V. Tigeeva,
  • V. A. Yakovlev,
  • D. N. Kisakov,
  • L. A. Kisakova,
  • L. I. Karpenko,
  • A. A. Ilyichev

摘要

The possibility of enhancing the immune response to a DNA vaccine encoding an artificial polyepitope T-cell immunogen containing a large number of conserved epitopes from different proteins of SARS-CoV-2 virus (pBSI-COV-Ub) was assessed by additional introduction of a plasmid encoding the secreted receptor-binding domain of the of SARS-CoV-2 S protein (pVAXrbd). Both a specific humoral response and a cellular response of broad specificity were observed in animals co-injected with pBSI-COV-Ub and pVAXrbd. This indicates the potential of this approach as a vaccine strategy.