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<p>The potential of a combination of decellularized tooth matrices and decellularized periodontal ligament in a collagen I hydrogel for periodontal regeneration was studied in a rat model of surgical periodontal defect. The results were evaluated using microcomputed tomography and histological and immunohistochemical methods on day 60. The bioengineered construct induced the formation of dental cement and new fibrous and bone tissues in the area of the periodontal ligament. This bioengineered construct can be considered as a possible bioscaffold for the restoration of the periodontal tissue.</p>

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Induction of Periodontal Endogenous Regeneration by 3D Bioscaffolds

  • 期刊论文

  • 发表日期：

    2025年5月1日

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  • A. A. Ivanov,
  • O. P. Popova,
  • A. V. Kuznetsova,
  • N. N. Butorina,
  • T. I. Danilova,
  • A. V. Latyshev,
  • O. O. Yanushevich

摘要

The potential of a combination of decellularized tooth matrices and decellularized periodontal ligament in a collagen I hydrogel for periodontal regeneration was studied in a rat model of surgical periodontal defect. The results were evaluated using microcomputed tomography and histological and immunohistochemical methods on day 60. The bioengineered construct induced the formation of dental cement and new fibrous and bone tissues in the area of the periodontal ligament. This bioengineered construct can be considered as a possible bioscaffold for the restoration of the periodontal tissue.