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<p>Studies on rats have demonstrated that successive threefold 30-min sessions of inhalation of an argon–oxygen mixture (Ar 70%/O<sub>2</sub> 30%) immediately after and on days 2 and 3 after ischemic stroke reduce neurological deficit, the area of vWF<sup>+</sup> staining in brain sections, and the number of Iba-1<sup>+</sup> and Cas-3<sup>+</sup> cells in the lesion focus and NeuN<sup>+</sup> cells in the penumbra. However, no differences in the lesion volume were detected by MRI. Argon–oxygen inhalations reduced neurological deficits through their influence on reparative processes within the lesion site.</p>

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The Effects of Threefold 30-Minute Inhalation Sessions of an Argon–Oxygen Mixture on a Photochemically Induced Ischemic Stroke Model in Rats

  • 期刊论文

  • 发表日期：

    2025年5月1日

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  • M. V. Sutormin,
  • E. A. Boeva,
  • D. N. Silachev,
  • E. I. Yakupova,
  • V. V. Antonova,
  • M. A. Lubomydrov,
  • S. N. Kalabushev,
  • A. V. Erchov,
  • O. A. Grebenchikov,
  • A. N. Kuzovlev

摘要

Studies on rats have demonstrated that successive threefold 30-min sessions of inhalation of an argon–oxygen mixture (Ar 70%/O2 30%) immediately after and on days 2 and 3 after ischemic stroke reduce neurological deficit, the area of vWF+ staining in brain sections, and the number of Iba-1+ and Cas-3+ cells in the lesion focus and NeuN+ cells in the penumbra. However, no differences in the lesion volume were detected by MRI. Argon–oxygen inhalations reduced neurological deficits through their influence on reparative processes within the lesion site.