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<p>The blockade of hyperpolarization-activated currents (<i>I</i><sub>f</sub>) (10<sup>–9</sup> and 10<sup>–5</sup> M) had a multidirectional effect on the left ventricular developed pressure and the maximum contraction rate of the isolated heart in healthy, sham-operated rats, and rats with experimental acute myocardial infarction (AMI). The duration of isolated heart contraction in the presence of the <i>I</i><sub>f</sub> blocker at both concentrations decreased in the group of healthy animals and did not change in sham-operated rats and rats with AMI. <i>I</i><sub>f</sub> blockade increased the duration of isolated heart relaxation in all groups. The duration of the contraction cycle under conditions of <i>I</i><sub>f</sub> blockade (10<sup>–9</sup> M) increased in sham-operated rats and rats with AMI and decreased in healthy rats. The maximum concentration of the blocker increased the duration of contraction cycle in all experimental groups.</p>

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Effect of If Current Blockade on Contractility of the Isolated Rat Heart after Acute Myocardial Infarction

  • 期刊论文

  • 发表日期：

    2025年4月1日

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  • A. M. Kuptsova,
  • A. L. Zefirov,
  • N. I. Ziyatdinova,
  • L. T. Mosolov,
  • T. L. Zefirov

摘要

The blockade of hyperpolarization-activated currents (If) (10–9 and 10–5 M) had a multidirectional effect on the left ventricular developed pressure and the maximum contraction rate of the isolated heart in healthy, sham-operated rats, and rats with experimental acute myocardial infarction (AMI). The duration of isolated heart contraction in the presence of the If blocker at both concentrations decreased in the group of healthy animals and did not change in sham-operated rats and rats with AMI. If blockade increased the duration of isolated heart relaxation in all groups. The duration of the contraction cycle under conditions of If blockade (10–9 M) increased in sham-operated rats and rats with AMI and decreased in healthy rats. The maximum concentration of the blocker increased the duration of contraction cycle in all experimental groups.