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<p>The systemic inflammatory response that develops after cardiac surgery with the use of cardiopulmonary bypass, has individual features of its course, and perioperative assessment of its activity can serve as a basis for the development of a personalized approach to predicting the development and severity of the course of postoperative complications. We found that patients with high risk of postoperative infectious and inflammatory complications are characterized by high blood levels of HIF-1α and VNN1 proteins before surgery, as well as 24 and 72 h after it, and high level of <i>HIF1A</i> expression in leukocytes 72 h after surgery. The obtained data are necessary for understanding the individual features of the course of the systemic inflammatory response that develops after surgical interventions, as well as for timely treatment of organ dysfunctions during intensive care.</p>

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Differences in the Blood Levels of HIF-1α and VNN1 and Expression of HIF1A and NFKB1 in Leukocytes in Cardiological Patients with Risk of Postoperative Complications

  • 期刊论文

  • 发表日期：

    2025年4月1日

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  • M. V. Silina,
  • D. Sh. Dzhalilova,
  • M. A. Diatroptova,
  • O. O. Grin,
  • M. A. Babaev,
  • O. V. Makarova

摘要

The systemic inflammatory response that develops after cardiac surgery with the use of cardiopulmonary bypass, has individual features of its course, and perioperative assessment of its activity can serve as a basis for the development of a personalized approach to predicting the development and severity of the course of postoperative complications. We found that patients with high risk of postoperative infectious and inflammatory complications are characterized by high blood levels of HIF-1α and VNN1 proteins before surgery, as well as 24 and 72 h after it, and high level of HIF1A expression in leukocytes 72 h after surgery. The obtained data are necessary for understanding the individual features of the course of the systemic inflammatory response that develops after surgical interventions, as well as for timely treatment of organ dysfunctions during intensive care.