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<p>We studied the histological structure of the hippocampus in male and female Wistar rats kept on a standard vivarium diet (StD) or a high-calorie diet (HCD) for 16 weeks. The effect of diet-induced visceral obesity correction was also evaluated. To this end, the rats receiving HCD for 8 weeks were transferred to StD for the next 8 weeks. HCD for 16 weeks led to diet-induced visceral obesity and disturbances in the histological structure of the hippocampus in both males and females. The most typical consequences of HCD were neurodegenerative signs, which appeared in different regions of the hippocampus. Transition to StD was effective not only in correcting visceral obesity, but also in leveling neurodegenerative changes in the structure of hippocampal neurons in male and female rats.</p>

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Histostructure of the Hippocampus in Male and Female Wistar Rats with Diet-Induced Visceral Obesity and after Diet Correction

  • 期刊论文

  • 发表日期：

    2025年3月1日

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  • T. E. Kuznetsova,
  • T. A. Mityukova,
  • A. A. Basalai,
  • M. A. Darenskaya,
  • L. V. Rychkova,
  • S. I. Kolesnikov,
  • N. V. Semenova,
  • L. I. Kolesnikova

摘要

We studied the histological structure of the hippocampus in male and female Wistar rats kept on a standard vivarium diet (StD) or a high-calorie diet (HCD) for 16 weeks. The effect of diet-induced visceral obesity correction was also evaluated. To this end, the rats receiving HCD for 8 weeks were transferred to StD for the next 8 weeks. HCD for 16 weeks led to diet-induced visceral obesity and disturbances in the histological structure of the hippocampus in both males and females. The most typical consequences of HCD were neurodegenerative signs, which appeared in different regions of the hippocampus. Transition to StD was effective not only in correcting visceral obesity, but also in leveling neurodegenerative changes in the structure of hippocampal neurons in male and female rats.