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<p>The expression of long non-coding RNAs (lncRNAs) PSMB8-AS1 and IGFL2-AS1, as well as associated microRNAs miR-802 and miR-382-3p, was analyzed in 42 paired samples of non-small cell lung cancer (NSCLC) with subsequent evaluation of their diagnostic and prognostic significance. The expression of PSMB8-AS1 was reduced in tumor tissue compared to normal lung tissue, while the expression levels of IGFL2-AS1, miR-802, and miR-382-3p were increased. The analysis of the clinical significance of the studied molecules showed that the expression of PSMB8-AS1 correlated with the histological type and localization of the tumor (<i>r</i> = -0.532, <i>p</i> = 0.0003, and <i>r</i> = -0.475, <i>p</i> = 0.003, respectively). ROC analysis for PSMB8-AS1 in the group of patients with squamous cell carcinoma showed that the area under the ROC curve was 0.904 (<i>p</i> &lt; 0.0001), indicating good quality of the diagnostic model and allows us to use the data obtained to further verify it. The analysis of the prognostic significance has shown that the studied non-coding RNAs in general are not prognostic factors for NSCLC. Additional subgroup analysis showed that PSMB8-AS1 is an unfavorable prognostic factor for squamous cell lung cancer (hazard ratio (HR)= 4.482, <i>p</i> = 0.027). Further investigation of non-coding RNAs in NSCLC is promising for identifying new markers for the diagnosis and prognosis of this disease.</p>

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Clinical Significance of Epigenetic Factors in the Development of Tumor Cell Resistance to the Cytotoxic Activity of Macrophages

  • 期刊论文

  • 发表日期：

    2025年3月1日

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  • O. V. Kovaleva,
  • P. A. Podlesnaya,
  • E. S. Kudinova,
  • V. V. Sinyov,
  • V. V. Mochalnikova,
  • N. E. Kushlinskii,
  • A. N. Gratchev

摘要

The expression of long non-coding RNAs (lncRNAs) PSMB8-AS1 and IGFL2-AS1, as well as associated microRNAs miR-802 and miR-382-3p, was analyzed in 42 paired samples of non-small cell lung cancer (NSCLC) with subsequent evaluation of their diagnostic and prognostic significance. The expression of PSMB8-AS1 was reduced in tumor tissue compared to normal lung tissue, while the expression levels of IGFL2-AS1, miR-802, and miR-382-3p were increased. The analysis of the clinical significance of the studied molecules showed that the expression of PSMB8-AS1 correlated with the histological type and localization of the tumor (r = -0.532, p = 0.0003, and r = -0.475, p = 0.003, respectively). ROC analysis for PSMB8-AS1 in the group of patients with squamous cell carcinoma showed that the area under the ROC curve was 0.904 (p < 0.0001), indicating good quality of the diagnostic model and allows us to use the data obtained to further verify it. The analysis of the prognostic significance has shown that the studied non-coding RNAs in general are not prognostic factors for NSCLC. Additional subgroup analysis showed that PSMB8-AS1 is an unfavorable prognostic factor for squamous cell lung cancer (hazard ratio (HR)= 4.482, p = 0.027). Further investigation of non-coding RNAs in NSCLC is promising for identifying new markers for the diagnosis and prognosis of this disease.