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<p>Therapeutic efficacy of olfactory ensheathing cells and type I collagen administered separately or in combination was studied in a model of chronic spinal cord injury in rats. The introduction of collagen hydrogel at a concentration of 4 mg/ml with and without olfactory ensheathing cells into spinal cord cysts reduced cyst volume and restored hindlimb motor function. The introduction of collagen hydrogel at both concentrations (1 and 4 mg/ml) with and without ensheathing cells stimulated remyelination of damaged nerve tissue. The results show that further study of this bioengineered preparation, as well as other combinations with cells or hydrogels is promising for the treatment of spinal cord injuries.</p>

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Application of Olfactory Ensheathing Cells in Collagen Hydrogels for Therapy of Experimental Spinal Cord Cysts

  • 期刊论文

  • 发表日期：

    2025年2月1日

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  • G. A. Fursa,
  • A. I. Mukhina,
  • A. V. Chadin,
  • E. K. Karsuntseva,
  • A. D. Voronova,
  • V. S. Shishkina,
  • P. A. Lazareva,
  • A. A. Stepanenko,
  • I. V. Reshetov,
  • O. V. Stepanova,
  • V. P. Chekhonin

摘要

Therapeutic efficacy of olfactory ensheathing cells and type I collagen administered separately or in combination was studied in a model of chronic spinal cord injury in rats. The introduction of collagen hydrogel at a concentration of 4 mg/ml with and without olfactory ensheathing cells into spinal cord cysts reduced cyst volume and restored hindlimb motor function. The introduction of collagen hydrogel at both concentrations (1 and 4 mg/ml) with and without ensheathing cells stimulated remyelination of damaged nerve tissue. The results show that further study of this bioengineered preparation, as well as other combinations with cells or hydrogels is promising for the treatment of spinal cord injuries.