Scholarlink

<p>We studied the psychopharmacological effects of a NF-κB inhibitor, a stimulator of the functions of progenitor cells of the nervous tissue, under conditions of modeled ethanol-induced encephalopathy. The pharmacological agent improved indicators of the orientation and exploratory behavior and reproducibility of the conditioned passive avoidance reflex in experimental animals. These effects developed against the background of a significant increase in the content and proliferative activity of neural stem cells in the subventricular zone of the brain and intensification of their specialization. The results indicate the prospects of developing fundamentally new agents with regenerative activity based on NF-κB blockers for the treatment of alcoholic encephalopathy.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Psychopharmacological and Neuroregenerative Effects of a NF-κB Inhibitor under Conditions of Modeled Ethanol-Induced Encephalopathy

  • 期刊论文

  • 发表日期：

    2025年2月1日

查看全文
  • G. N. Zyuz’kov,
  • V. V. Zhdanov,
  • L. A. Miroshnichenko,
  • T. Yu. Polyakova,
  • E. V. Simanina,
  • A. V. Chaykovskyi,
  • V. I. Agafonov

摘要

We studied the psychopharmacological effects of a NF-κB inhibitor, a stimulator of the functions of progenitor cells of the nervous tissue, under conditions of modeled ethanol-induced encephalopathy. The pharmacological agent improved indicators of the orientation and exploratory behavior and reproducibility of the conditioned passive avoidance reflex in experimental animals. These effects developed against the background of a significant increase in the content and proliferative activity of neural stem cells in the subventricular zone of the brain and intensification of their specialization. The results indicate the prospects of developing fundamentally new agents with regenerative activity based on NF-κB blockers for the treatment of alcoholic encephalopathy.