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<p>The UV spectra of induced autofluorescence in the skin of children and adolescents with type 1 diabetes mellitus were studied and its relationships with sex, age, duration of diabetes, and chronic complications of the disease were evaluated. The data were presented as a 2D array, the fluorescence spectra were normalized, smoothed by the moving average method with a window of 10 nm, and renormalized taking into account the coefficients found. Significant differences in skin fluorescence spectra were found in children of different ages, with increasing the disease duration and depending on the sex of the patients. When developing non-invasive methods of monitoring the state of carbohydrate metabolism, it is necessary to take into account sex and age, disease duration, and the presence of complications of type 1 diabetes mellitus.</p>

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Skin Autofluorescence in Children with Type 1 Diabetes Mellitus, Correlation with Age, Sex, Duration, and Presence of Microvascular Complications

  • 期刊论文

  • 发表日期：

    2025年2月1日

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  • M. V. Proskurina,
  • T. E. Taranushenko,
  • V. V. Salmin,
  • N. G. Kiseleva

摘要

The UV spectra of induced autofluorescence in the skin of children and adolescents with type 1 diabetes mellitus were studied and its relationships with sex, age, duration of diabetes, and chronic complications of the disease were evaluated. The data were presented as a 2D array, the fluorescence spectra were normalized, smoothed by the moving average method with a window of 10 nm, and renormalized taking into account the coefficients found. Significant differences in skin fluorescence spectra were found in children of different ages, with increasing the disease duration and depending on the sex of the patients. When developing non-invasive methods of monitoring the state of carbohydrate metabolism, it is necessary to take into account sex and age, disease duration, and the presence of complications of type 1 diabetes mellitus.