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<p>Innate immune cells have the ability to acquire non-specific immunological memory (NIM), which provides resistance to a variety of bacterial and viral infections. Experiments <i>in vitro</i> and <i>in vivo</i> have verified the hypothesis that the farnesyl pyrophosphate synthase inhibitor (aminobisphosphonates) can potentiate BCG-induced NIM. The aminobisphosphonate zoledronate induced the NIM phenotype in human monocyte cultures and provided nonspecific protection against staphylococcal infection in mice. Additionally, zoledronate significantly enhanced BCG-induced NIM, resulting in a synergistic protective effect. The phenomenon of potentiation of NIM/anti-infectious resistance discovered by us can form the basis for designing powerful universal vaccines of a new type.</p>

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Aminobisphosphonates Potentiate Non-Specific Immunological Memory

  • 期刊论文

  • 发表日期：

    2025年2月1日

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  • Y. Sh. Schwartz,
  • O. V. Semenova,
  • A. V. Salmin

摘要

Innate immune cells have the ability to acquire non-specific immunological memory (NIM), which provides resistance to a variety of bacterial and viral infections. Experiments in vitro and in vivo have verified the hypothesis that the farnesyl pyrophosphate synthase inhibitor (aminobisphosphonates) can potentiate BCG-induced NIM. The aminobisphosphonate zoledronate induced the NIM phenotype in human monocyte cultures and provided nonspecific protection against staphylococcal infection in mice. Additionally, zoledronate significantly enhanced BCG-induced NIM, resulting in a synergistic protective effect. The phenomenon of potentiation of NIM/anti-infectious resistance discovered by us can form the basis for designing powerful universal vaccines of a new type.