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<p>The receptor mechanism of the antinociceptive effect of the diterpene alkaloid songorine was investigated in an experiment on mice. Antagonists of peripheral opioid, κ-opioid, and cannabinoid 1 receptors eliminated the analgesic effect of songorine. These findings suggest that these receptors are involved in the antinociceptive action of songorine.</p>

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Involvement of Receptor Apparatus in the Realization of Antinociceptive Activity of Songorine

  • 期刊论文

  • 发表日期：

    2025年2月1日

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  • Yu. V. Nesterova,
  • A. V. Mukhomedzyanov,
  • T. N. Povetyeva,
  • N. I. Suslov,
  • P. V. Kul’pin,
  • O. G. Afanas’eva,
  • A. V. Vychuzhanina,
  • O. Yu. Rybalkina,
  • G. N. Zyuz’kov,
  • V. V. Zhdanov,
  • M. Yu. Minakova

摘要

The receptor mechanism of the antinociceptive effect of the diterpene alkaloid songorine was investigated in an experiment on mice. Antagonists of peripheral opioid, κ-opioid, and cannabinoid 1 receptors eliminated the analgesic effect of songorine. These findings suggest that these receptors are involved in the antinociceptive action of songorine.