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<p>We studied the sensitivity of clinically significant (opportunistic) bacteria to blood serum fraction with a molecular weight &lt;100 kDa containing antimicrobial peptides and proteins. The degree of damage to cytoplasmic membranes of bacterial cells was assessed by a spectrophotometric method. A total of 129 bacterial isolates belonging to 46 species, 19 genera, 13 families, 8 orders, 4 classes, and 3 types were studied. The mean sensitivity varied from -5.2 to 36.6%. The sensitivity depends on the structure of bacterial cell wall: higher sensitivity was demonstrated by taxonomic ranks related to gram-negative bacteria (median 19.1%) and lower values were observed in gram-positive bacteria (median 9.3%) (<i>p</i>&lt;0.01). Among all orders, <i>Lactobacilliales</i> showed the lowest sensitivity (3.6%). Ranking of the studied species by their sensitivity showed that 7 of the first 15 species with sensitivity &gt;19% are among to the leading causative agents of sepsis.</p>

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The Sensitivity of Opportunistic Bacteria to Blood Serum Low-Molecular Fraction Containing Antimicrobial Peptides and Proteins

  • 期刊论文

  • 发表日期：

    2025年1月1日

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  • A. M. Iksanova,
  • I. M. Ojovan,
  • V. G. Arzumanian,
  • N. O. Vartanova,
  • A. V. Poddubikov,
  • T. I. Kolyganova,
  • S. Yu. Konanykhina

摘要

We studied the sensitivity of clinically significant (opportunistic) bacteria to blood serum fraction with a molecular weight <100 kDa containing antimicrobial peptides and proteins. The degree of damage to cytoplasmic membranes of bacterial cells was assessed by a spectrophotometric method. A total of 129 bacterial isolates belonging to 46 species, 19 genera, 13 families, 8 orders, 4 classes, and 3 types were studied. The mean sensitivity varied from -5.2 to 36.6%. The sensitivity depends on the structure of bacterial cell wall: higher sensitivity was demonstrated by taxonomic ranks related to gram-negative bacteria (median 19.1%) and lower values were observed in gram-positive bacteria (median 9.3%) (p<0.01). Among all orders, Lactobacilliales showed the lowest sensitivity (3.6%). Ranking of the studied species by their sensitivity showed that 7 of the first 15 species with sensitivity >19% are among to the leading causative agents of sepsis.