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<p>We studied the effect of a krypton—oxygen mixture on the key signaling pathways associated with ischemic tolerance and suppression of secondary damage in a model of photoinduced stroke in male Wistar rats. In animals breathing the krypton—oxygen mixture, the expression of the transcription factor NF-κB (p50) in the brain was suppressed, indicating anti-inflammatory shifts in the brain tissue upon exposure to krypton, in parallel, increased content of phosphorylated forms of glycogen synthase kinase 3β (GSK-3β) and protein kinase B (Akt), components of the preconditioning cascade, was revealed. These results indicate a high potential of krypton in reducing acute cerebral disorders.</p>

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Effect of Breathing a Krypton—Oxygen Mixture on Signaling Cascades in Rat Brain during Simulation of Photoinduced Ischemic Stroke

  • 期刊论文

  • 发表日期：

    2025年1月1日

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  • V. V. Antonova,
  • I. V. Shumov,
  • V. T. Dolgikh,
  • A. A. Grebenchikova,
  • M. V. Gabitov,
  • E. I. Yakupova,
  • O. A. Grebenchikov

摘要

We studied the effect of a krypton—oxygen mixture on the key signaling pathways associated with ischemic tolerance and suppression of secondary damage in a model of photoinduced stroke in male Wistar rats. In animals breathing the krypton—oxygen mixture, the expression of the transcription factor NF-κB (p50) in the brain was suppressed, indicating anti-inflammatory shifts in the brain tissue upon exposure to krypton, in parallel, increased content of phosphorylated forms of glycogen synthase kinase 3β (GSK-3β) and protein kinase B (Akt), components of the preconditioning cascade, was revealed. These results indicate a high potential of krypton in reducing acute cerebral disorders.