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<p>We studied the effect of α<sub>2</sub>-adrenoreceptor stimulation after preliminary <i>I</i><sub>f</sub> blockade on the function of the Langendorff-isolated rat heart in the acute stage of experimental myocardial infarction. Stimulation of α<sub>2</sub>-adrenoreceptors with clonidine (10<sup>—6</sup> M) against the background of <i>I</i><sub>f</sub> blockade with ZD7288 (10<sup>—9</sup> M) reduced the contractility of the left ventricular myocardium, HR, coronary blood flow, and the duration of the left ventricular myocardium contraction in sham-operated rats and animals with acute myocardial infarction. The duration of relaxation and contraction cycle during α<sub>2</sub>-adrenoreceptor stimulation after preliminary <i>I</i><sub>f</sub> blockade (10<sup>—9</sup> M) was increased in sham-operated rats and in animals with acute myocardial infarction. Stimulation of adrenoreceptors against the background of application of ZD7288 in a concentration of 10<sup>—5</sup> M decreased the left ventricular pressure, HR, coronary blood flow, and the duration of left ventricular myocardial contraction in both groups. The duration of the relaxation and contraction cycle during α<sub>2</sub>-adrenoreceptor stimulation against the background of <i>I</i><sub>f</sub> blockade (10<sup>—5</sup> M) increased in sham-operated rats and animals with acute myocardial infarction.</p>

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The Effect of α2-Adrenergic Receptor Stimulation on the Isolated Hearts from Rats with Acute Myocardial Infarction against the Background of If Blockade

  • 期刊论文

  • 发表日期：

    2025年1月1日

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  • N. I. Ziyatdinova,
  • A. M. Kuptsova,
  • L. I. Faskhutdinov,
  • R. R. Shakirov,
  • T. L. Zefirov

摘要

We studied the effect of α2-adrenoreceptor stimulation after preliminary If blockade on the function of the Langendorff-isolated rat heart in the acute stage of experimental myocardial infarction. Stimulation of α2-adrenoreceptors with clonidine (10—6 M) against the background of If blockade with ZD7288 (10—9 M) reduced the contractility of the left ventricular myocardium, HR, coronary blood flow, and the duration of the left ventricular myocardium contraction in sham-operated rats and animals with acute myocardial infarction. The duration of relaxation and contraction cycle during α2-adrenoreceptor stimulation after preliminary If blockade (10—9 M) was increased in sham-operated rats and in animals with acute myocardial infarction. Stimulation of adrenoreceptors against the background of application of ZD7288 in a concentration of 10—5 M decreased the left ventricular pressure, HR, coronary blood flow, and the duration of left ventricular myocardial contraction in both groups. The duration of the relaxation and contraction cycle during α2-adrenoreceptor stimulation against the background of If blockade (10—5 M) increased in sham-operated rats and animals with acute myocardial infarction.