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<p>We studied the influence of the α<sub>1</sub>-adrenergic receptor agonist methoxamine on the frequency of spontaneous activity and the parameters of electrical activity of the atrial myocardium from 21-day-old rats with normal sinus (preserved sinus node) or paced rhythm. Stimulation with methoxamine increased the frequency of spontaneous activity. Under the conditions of preserved sinus rhythm, the α<sub>1</sub>-adrenergic agonist decreased the duration of the repolarization phase of the action potential, whereas at paced rhythm, this parameter increased.</p>

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The Role of α1-Adrenergic Receptors in the Regulation of Electrical Activity of Right Atrial Myocardiocytes from 21-Day-Old Rats

  • 期刊论文

  • 发表日期：

    2025年1月1日

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  • N. Mansour,
  • A. L. Zefirov,
  • N. I. Ziyatdinova,
  • A. M. Kuptsova,
  • T. L. Zefirov

摘要

We studied the influence of the α1-adrenergic receptor agonist methoxamine on the frequency of spontaneous activity and the parameters of electrical activity of the atrial myocardium from 21-day-old rats with normal sinus (preserved sinus node) or paced rhythm. Stimulation with methoxamine increased the frequency of spontaneous activity. Under the conditions of preserved sinus rhythm, the α1-adrenergic agonist decreased the duration of the repolarization phase of the action potential, whereas at paced rhythm, this parameter increased.