The Study of Effectiveness of Combined Proton—Neutron Irradiation of Tumor Cells In Vitro

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发表日期：

2024年11月22日

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S. N. Koryakin,
M. V. Troshina,
E. V. Koryakina,
V. I. Potetnya,
A. A. Pichkunova,
V. O. Saburov,
E. I. Kazakov,
A. A. Lychagin,
S. A. Ivanov,
A. D. Kaprin,
V. I. Zverev,
A. Yu. Presnyakov

摘要

Combined proton—neutron therapy can be the best opportunity for neutron radiation therapy due to highly conformal proton irradiation and high relative biological effectiveness of neutrons. The study compares 4 schemes of sequential in vitro exposure of Chinese hamster fibrosarcoma cells B14-150 to 14.5 MeV neutrons and a scanning beam of protons. Treatment efficiency increased with increasing the contribution of the neutron component to the total dose from 30 to 40% and the delivery of the neutron dose as the first fraction in the two-fraction proton—neutron exposure.