Age-Related Features of the Function of the Hypothalamic—Pituitary—Thyroid (HPT) Axis in Nonhuman Primates under Constant Lighting
摘要
We studied the features of the functioning of the hypothalamic—pituitary—thyroid (HPT) axis under conditions of constant (4 weeks) lighting (LED lamps intended for office and residential premise) on a translational model of young adult and old female rhesus monkeys, in particular taking into account their behavior. Constant lightning had no significant effect on the levels of thyroid-stimulating hormone, thyroxine, and triiodothyronine under basal conditions in all animals, regardless of age and behavioral characteristics, but induced a decrease in thyroid function under conditions of its activation with thyrotropin-releasing hormone, mainly in old animals.