Comparative Assessment of the Influence of Embolizing Agents on the Adrenal Parenchyma

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发表日期：

2024年8月1日

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M. S. Annayev,
K. V. Stegniy,
B. I. Geltser,
R. A. Goncharuk,
S. M. Seliutin,
E. V. Maslyantsev,
V. G. Fisenko,
E. R. Dvoinikova,
L. V. Zvereva

摘要

A comparative analysis of morphological and functional changes in the adrenal glands after embolization of supplying arteries with Lifepearl microspheres (100±25 μm; Terumo) and with a solution of polidocanol (Aethoxysklerol, Kreussler Pharma) was performed in male Vietnamese Lop-Bellied pigs (n=20). The introduction of the microspheres into the arterial bed did not affect the adrenal parenchyma. However, the injection of the liquid sclerosing agent caused foci of productive inflammation leading to the formation of sclerotic tissue and reduction of the volume of glandular tissue. Administration of the sclerosant was accompanied by arterial hypotension, an indirect indication of a decrease in vasoactive hormone production by the adrenal cortex. These findings suggest that polidocanol can be used as an embolization agent for hyperplastic diseases of the adrenal cortex.