Use of Adjuvant Compositions Based on Squalene Ensures Induction of Neutralizing Antibodies against SARS-CoV-2

期刊论文
发表日期：

2024年6月1日

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E. A. Volosnikova,
N. V. Volkova,
V. V. Ermolaev,
M. B. Borgoyakova,
V. S. Nesmeyanova,
A. V. Zaykovskaya,
O. V. Pyankov,
B. N. Zaitsev,
S. V. Belenkaya,
A. A. Isaeva,
D. N. Shcherbakov

摘要

Squalene-based adjuvant compositions that can provide effective induction of specific humoral immune response have been developed. Recombinant receptor-binding domain (RBD) of surface S-protein of SARS-CoV-2 was used to evaluate the properties of the composition. Immunization of mice with the developed squalene-based compositions in combination with RBD allows obtaining high titers of specific antibodies: from 10⁵ to 2×10⁶. The blood sera from immunized mice exhibit neutralizing activity against SARS-CoV-2 Delta variant (B.1.617.2) with a titer up to 1:2000.