Effect of Trehalose Disaccharide on Activation of Microglia and Indices of Systemic Inflammation in an Experimental Model of Alzheimer’s Disease

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发表日期：

2024年6月1日

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S. A. Zozulya,
A. A. Akopyan,
M. V. Tenditnik,
M. V. Ovsyukova,
T. A. Korolenko,
T. P. Klyushnik,
M. A. Tikhonova,
A. B. Pupyshev

摘要

In an experimental model of Alzheimer’s disease in mice, oral administration of trehalose disaccharide reduces neuroinflammation assessed by the expression level of microglia activation marker Iba1 and affects the neutrophil degranulation activity. A potential anti-inflammatory effect of 4% trehalose solution associated with a decrease in the activity of leukocyte elastase in plasma was revealed.