Analgesic and Psychotropic Effects of a New Bradykinin Antagonist

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发表日期：

2024年3月1日

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A. E. Aliforenko,
V. S. Motov,
V. V. Bykov,
A. V. Bykova,
V. I. Pavlovsky,
V. V. Larchenko,
V. A. Khazanov,
A. I. Vengerovskii

摘要

A bradykinin B₁ receptors antagonist PAV-0056, an 1,4-benzodiazepin-2-one derivative, intragastrically administrated to mice at doses of 0.1 and 1 mg/kg causes analgesia in the “formalin test” not inferior to that of diclofenac sodium (10 mg/kg) and tramadol (20 mg/kg). PAV-0056 at doses of 0.1 and 10 mg/kg has no anxiolytic and central muscle relaxant effects in mice and does not damage the gastric mucosa in rats. Based on the results of the conditioned place preference test, PAV-0056 also does not induce addiction in mice.