Age-Related Features of the Response of Cancer Stem Cells and T Cells in Experimental Lung Cancer

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发表日期：

2024年2月1日

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O. V. Pershina,
N. N. Ermakova,
A. V. Pakhomova,
E. S. Pan,
L. A. Sandrikina,
M. A. Zhukova,
L. V. Kogai,
A. M. Dygai,
E. G. Skurikhin

摘要

The responses of tumor stem cells and various populations of CD4 and CD8 T cells of young and aged C57BL/6 mice were studied in a lung cancer model. Using Lewis lung carcinoma cell line, an orthotopic model of lung cancer was modeled. Cancer stem cells, circulating tumor cells, and various populations of CD4 and CD8 T cells in the blood and lung tissue were studied by cytometry. We revealed age-related differences in the content of various populations of CD4 and CD8 T cells in the blood and lungs of intact young and aged mice. Age-related features of the reaction of various populations of cancer stem cells and CD4 and CD8 T cells in the blood and lungs of animals in the Lewis lung carcinoma were shown.