Dynamics of Changes in the cAMP/cGMP Concentration Ratio in the Thymus and Spleen of Laboratory Mice during Vaccination against Plague and Tularemia against the Background of Immunomodulation

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发表日期：

2024年2月1日

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V. I. Dubrovina,
O. V. Yur’eva,
A. B. Pyatidesyatnikova,
T. P. Starovoitova,
S. V. Balakhonov

摘要

Vaccine strains Yersinia pestis EV NIIEG at a dose of 10³ CFU and Francisella tularensis 15 NIIEG at a dose of 10² CFU induced changes in the concentration of cyclic nucleotides in the thymus and spleen of white mice. Antigen-induced changes in the cAMP/cGMP ratio in immunocompetent organs had a phase or oscillatory character, which seems to be related to the regulation of postvaccination immunoreactivity in the body. Synthetic organoselenium compound 974zh stimulated an increase in the amplitude of cAMP/cGMP oscillations, indicating its stimulating effect on the immunogenic properties of vaccine strains at doses an order of magnitude below the standard doses.