Characterization of Risk Factors for Modeling of Type 2 Diabetes Mellitus Induced by a High-Fat Diet in C57BL/6 Mice

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发表日期：

2024年2月1日

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N. A. Borozdina,
E. R. Shaikhutdinova,
G. A. Slashcheva,
N. A. Goryacheva,
A. V. Zamyatina,
E. S. Sadovnikova,
I. A. Pakhomova,
V. M. Pavlov,
N. A. Perepechenova,
M. S. Severyukhina,
A. Yu. Fedotova,
D. V. Popkova,
I. N. Gladkikh,
E. V. Leichenko,
I. A. Dyachenko

摘要

Type 2 diabetes mellitus develops due to a combination of genetic and environmental factors. C57BL/6 mice prone to obesity and leptin resistance were kept on a high-fat diet for 21 weeks. The animals showed a significant increase in fasting and postprandial glucose levels and body weight, the development of insulin resistance, and by week 18, an increase in the serum TNFα level. Metformin therapy at a dose of 250 mg/kg was effective against the background of disturbances in carbohydrate metabolism: animals showed a significant decrease in insulin resistance and TNFα level.