<p>Our intention is to show how Leonardo da Vinci applied the geometric method of the golden ratio, as conveyed in the work of his friend Luca Pacioli <i>De Divina Proportione</i>. It is not about the stencilled application of geometric rules, but about the artist’s creative eye, which is shaped by experience and produces beauty in the process. It is a continuation of the artistic practice of antiquity that characterised the artistic and scientific creation of the High Renaissance. This paper also explores the extent to which Leonardo’s model of science could serve us today as an orientation for redefining and transforming science from the perspective of our lifeworld. To this end, the question is raised as to whether we can approach the scientific model that Leonardo represented from the perspective of interdisciplinarity, whereby ethical reflection is integrated into the scientific discourse.</p>