<p>The NIKIET JSC (Moscow, Russian Federation) develops a&#xa0;blanket design for producing nuclear fuel in a&#xa0;hybrid fusion-fission plant. The present paper reviews the issues and challenges solved within the framework of these activities. A&#xa0;set of issues, both physical and engineering, connected with the approaches to the design, organization, and functioning of isotope-producing blanket is analyzed. Main conclusions on the required design approaches to the maximum use of the hybrid fusion-fission plant potential are provided. The estimated rates of producing ²³⁹Pu and ²³³U in a&#xa0;blanket based on ²³⁸U and ²³²Th raw isotopes, respectively, are given. In addition, the paper presents considerations regarding the strategic development line of hybrid fusion-fission, leading to the development of an industrial nuclear fuel production facility, including the stages of experimental development of the relevant technologies based on experimental and pilot-industrial plants.</p>