<p>Pre-exposure prophylaxis (PrEP) is a powerful HIV infection prevention tool. We aimed to determine how PrEP users evaluated its impact on different aspects of their sex life. We elaborated and disseminated an online questionnaire on social media and through billboards in consultation waiting rooms of sexually transmitted infection clinics or hospital infectious diseases units. The questionnaire featured nine questions from the New Sexual Satisfaction Scale and seven further questions to explore participants’ experience. Participants were also asked to evaluate their sex life under PrEP on a 0–100 scale and the negative/positive impact of PrEP on their sex life on a − 100 to + 100 scale. Lastly, participants were asked the extent to which PrEP modified their self-esteem and whether different parts of the PrEP program were important. The study included 459 persons currently on PrEP: 95.4% were males and 92.4% were men having sex with men. Median age was 39&#xa0;years. Most initiated PrEP in 2020 or afterwards. Most participants reported a positive impact of PrEP, particularly regarding “my ‘letting go’ during sex,” “my emotional opening up during sex,” “my mood after sexual activity,” and “the quality of my orgasms.” A total of 81.7% agreed that “Overall, my sex life has improved under PrEP”. Participants evaluated the quality of their sex life as 80 (IQR 70–90) and the impact of PrEP as 80 (IQR 50–95). A total of 51.1% Considered that PrEP had improved their self-esteem. In conclusion, PrEP users report it improved their sex life. This should be mentioned when proposing PrEP.</p>