<p>Sustainability is a critical concept in the aquaculture industry, ensuring the efficient use of existing resources for the production of aquatic organisms while considering economic, social, and environmental factors. Two primary strategies for advancing sustainability include improving feed efficiency and transitioning to organic compounds as alternatives to synthetic chemicals. Nature-identical compounds, including 1,8-cineole, have emerged as promising candidates due to their versatility in enhancing production and welfare. This review examines the potential applications of 1,8-cineole in aquaculture. Bibliometric screening identified 84 relevant records, highlighting a focus on chemical characterization, biological responses, and physiological assessments. The findings indicate that 1,8-cineole can promote fish growth performance and health; however, a critical knowledge gap persists regarding its pharmacokinetics (ADME) in aquatic species, preventing the establishment of safe and effective dosage protocols for aquaculture species. Furthermore, regarding antimicrobial efficacy, while in vitro studies have demonstrated inhibitory effects against fish-pathogenic bacteria, there is a notable absence of in vivo challenge trials against bacterial or viral pathogens to confirm these results in live organisms. Additionally, research on its effects on aquatic crustaceans, disease resistance, and the intestinal microbiome remains limited. Given the promising results in non-aquatic subjects, these areas warrant urgent investigation, with a primary emphasis on pharmacokinetic profiling and in vivo infection validation.</p>