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<p>Early-onset ovarian insufficiency (POI) is a heterogeneous disorder characterized by complex etiology and the involvement of diverse programmed cell death modalities. This review aims to systematically elucidate the molecular mechanisms underlying programmed cell death in the pathogenesis of POI, with an emphasis on regulatory signaling networks and the dynamic switching of cell death modalities under distinct etiological contexts. We summarize the roles of key programmed cell death pathways—including apoptosis, pyroptosis, ferroptosis, necroptosis, and autophagic cell death—in the onset and progression of POI. In addition, potential therapeutic strategies targeting dysregulated cell death processes are briefly discussed.</p>

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Relationship between different modes of death and premature ovarian insufficiency: a literature review

  • 期刊论文

  • 发表日期：

    2026年4月16日

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  • Huihui Li,
  • Ruotong Ju,
  • Puhua zhang,
  • Chenyu Jia,
  • Tingting Xue,
  • Shu Wang,
  • Xinyu Zhu,
  • Ruixiang Zhu,
  • Jiali Luo,
  • Xuan Jing,
  • Xiangrong Cui

摘要

Early-onset ovarian insufficiency (POI) is a heterogeneous disorder characterized by complex etiology and the involvement of diverse programmed cell death modalities. This review aims to systematically elucidate the molecular mechanisms underlying programmed cell death in the pathogenesis of POI, with an emphasis on regulatory signaling networks and the dynamic switching of cell death modalities under distinct etiological contexts. We summarize the roles of key programmed cell death pathways—including apoptosis, pyroptosis, ferroptosis, necroptosis, and autophagic cell death—in the onset and progression of POI. In addition, potential therapeutic strategies targeting dysregulated cell death processes are briefly discussed.