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<p>Emerging as a novel secreted protein, Meteorin-like (Metrnl) exhibits substantial sequence homology with Meteorin (Metrn). Although Metrnl was initially identified in the context of adipose tissue and metabolic regulation, accumulating evidence has demonstrated its widespread expression across multiple tissues, including the nervous system, barrier tissues, and skeletal muscle. Functionally, Metrnl exerts pleiotropic biological effects and has been implicated as an adipokine, an immunomodulatory factor, and a cytoprotective mediator. This review provides an overview of current knowledge regarding the tissue-specific actions of Metrnl and summarizes the major signaling pathways associated with its activity. The integral role of Metrnl across different systems in both health and disease states is further examined, with a focus on elucidating its pathological involvement in various human disorders.</p>

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Metrnl in health and disease: tissue-specific actions and signaling networks

  • 期刊论文

  • 发表日期：

    2026年3月7日

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  • Ran Zhao,
  • Yue Qi,
  • Pan Li,
  • Zhe Zhang,
  • YiYang Chen,
  • Xiaopeng Wu,
  • Wei Wang,
  • Xiaoqing Guo,
  • Huadong Zhao,
  • Yang Yang,
  • Xiaowu Wang

摘要

Emerging as a novel secreted protein, Meteorin-like (Metrnl) exhibits substantial sequence homology with Meteorin (Metrn). Although Metrnl was initially identified in the context of adipose tissue and metabolic regulation, accumulating evidence has demonstrated its widespread expression across multiple tissues, including the nervous system, barrier tissues, and skeletal muscle. Functionally, Metrnl exerts pleiotropic biological effects and has been implicated as an adipokine, an immunomodulatory factor, and a cytoprotective mediator. This review provides an overview of current knowledge regarding the tissue-specific actions of Metrnl and summarizes the major signaling pathways associated with its activity. The integral role of Metrnl across different systems in both health and disease states is further examined, with a focus on elucidating its pathological involvement in various human disorders.