Scholarlink

<p>Melanoma&#xa0;is the most aggressive and deadly form of skin cancer. However, advances in the understanding of its biology have led to the development of several new therapeutic approaches. One of these novel treatment strategies is based on the targeting of the mitochondrial bioenergetic and networks responsible for tumor initiation and progression. Indeed, it has recently emerged that changes in mitochondrial metabolism, dynamics, redox homeostasis, and apoptosis are strictly associated with tumor growth, metastasis, and drug resistance. In this review, we summarize current evidence about the multiple biological functions exerted by mitochondria in melanoma, also focusing on the role of these organelles as promising targets for pharmacological intervention.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Mitochondrial bioenergetics and networks in melanoma: an update

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月28日

查看全文
  • Gaia Giannitti,
  • Alyssa Julia Jennifer Paganoni,
  • Sara Marchesi,
  • Riccardo Garavaglia,
  • Fabrizio Fontana

摘要

Melanoma is the most aggressive and deadly form of skin cancer. However, advances in the understanding of its biology have led to the development of several new therapeutic approaches. One of these novel treatment strategies is based on the targeting of the mitochondrial bioenergetic and networks responsible for tumor initiation and progression. Indeed, it has recently emerged that changes in mitochondrial metabolism, dynamics, redox homeostasis, and apoptosis are strictly associated with tumor growth, metastasis, and drug resistance. In this review, we summarize current evidence about the multiple biological functions exerted by mitochondria in melanoma, also focusing on the role of these organelles as promising targets for pharmacological intervention.